A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
- Trial number:
- NCT05152147
- Trial phase:
- 3
- Study type:
- Immunotherapy, Targeted therapy, Chemotherapy, Biomarker
- Overall status:
- Recruiting
Study start date
December, 2021
Scientific title
A Randomized, Multicenter, Phase 3 Study of Zanidatamab in Combination With Chemotherapy With or Without Tislelizumab in Subjects With HER2-positive Unresectable Locally Advanced or Metastatic Gastroesophageal Adenocarcinoma (GEA)
Summary
This study is being done to find out if zanidatamab, when given with chemotherapy plus or minus tislelizumab, is safe and works better than trastuzumab given with chemotherapy.
The patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esophageal cancers that are no longer treatable with surgery (unresectable) or chemoradiation, and/or have grown or spread to other parts of the body (metastatic).
Histologically confirmed unresectable locally advanced, recurrent or metastatic HER2-positive gastroesophageal adenocarcinoma (adenocarcinomas of the stomach or esophagus, including the gastroesophageal junction), defined as 3+ HER2 expression by IHC or 2+ HER2 expression by IHC with ISH positivity per central assessment. Subjects with esophageal adenocarcinoma must not be eligible for combined chemoradiotherapy at the time of enrollmentAssessable (measurable or non-measurable) disease as defined by RECIST 1.1 Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1, assessed within 3 days prior to randomization Adequate organ function Left ventricular ejection fraction (LVEF) ≥ 50% as determined by either echocardiogram or multiple gated acquisition scan (MUGA)
Study design
Primary purpose:
Treatment, Allocation:
Randomized, Intervention model:
Parallel Assignment, Intervention model description:
multi-cohort, open-label, multicenter study, Masking:
None (Open Label),
Conditions
Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma
Other study ID numbers
ZWI-ZW25-301; 2021-000296-36; jRCT2061230026
Choose trial site (419)
Foshan First People's Hospital
Fo Shan Shi Di Yi Ren Min Yi Yuan, 石湾 Chan Cheng Qu, Fo Shan Shi, Guang Dong Sheng, China, 528041
Tianjin Medical University General Hospital
154 Anshan Ave, He Ping Qu, China, 300052
The Tonghua Central Hospital
China, Ji Lin Sheng, Tong Hua Shi, Dong Chang Qu, 新光路176号 邮政编码: 134000
Union Hospital Tongji Medical College HuaZhong University of Science and Technology
China, Hu Bei Sheng, Wu Han Shi, Jiang An Qu, 三阳路 邮政编码: 430014
Bioclinic Thessaloniki Oncology Department
Mitropoleos 86, Thessaloniki 546 22, Greece
Interbalkan Medical Center of Thessaloniki Oncology Department
Asklipiou 10, Pilea 555 35, Greece
Hallym University Sacred Heart Hospital
South Korea, Gyeonggi-do, Anyang, Dongan-gu, Gwanpyeong-ro 170beon-gil, 22 KR
Dong-A University Hospital
26 Daesingongwon-ro, Seo-gu, Busan, South Korea
Kyungpook National University Chilgok Hospital
130 Dongdeok-ro, Jung-gu, Daegu, South Korea
Gachon University Gil Medical Center
21 Namdong-daero 774beon-gil, Guwol-dong, Namdong-gu, Incheon, South Korea
Seoul National University Bundang Hospital
South Korea, Gyeonggi-do, Seongnam-si, Bundang-gu, Gumi-ro 173(baekchilsipsam)beo, 82 KR
Korea University Anam Hospital
South Korea, Seoul, Seongbuk-gu, 고려대로 73
Seoul National University Hospital
3699 Wilshire Blvd #730, Los Angeles, CA 90010, USA
Asan Medical Center
88 Olympic-ro 43-gil, Songpa-gu, Seoul, South Korea
Samsung Medical Center
81 Irwon-ro, Gangnam-gu, Seoul, South Korea
Korea University Guro Hospital
148 Gurodong-ro, Guro-dong, Guro-gu, Seoul, South Korea
Corporacio Sanitaria Parc Tauli
Parc Taulí, 1, 08208 Sabadell, Barcelona, Spain
Complejo Hospitalario de Navarra
C. de Irunlarrea, 3, 31008 Pamplona, Navarra, Spain
Hospital Universitario La Paz - PPDS
P.º de la Castellana, 261, 28046 Madrid, Spain
Hospital Universitario Miguel Servet
P.º Isabel la Católica, 1-3, 50009 Zaragoza, Spain
MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council
Kryvyi Rih, Dnipropetrovsk Oblast, Ukraine, 50000
The Municipal Enterprise Volyn Regional Medical Oncology Centre of the Volyn Regional Council
Lutsk, Volyn Oblast, Ukraine
Centro de Estudios Clínicos SAGA SpA
Antonio Varas 517, Providencia, Región Metropolitana, Chile
Sociedad Oncovida S.A
Gral. Holley 2381, Providencia, Región Metropolitana, Chile
BIOCINETIC SpA
Santiago, Santiago Metropolitan Region, Chile
Beijing Tiantan Hospital, Capital Medical University
China, Bei Jing Shi, Dong Cheng Qu, 北京市东城区天坛西里6号 邮政编码: 100061
Beijing Cancer Hospital
52 Fu Cheng Lu, Hai Dian Qu, Bei Jing Shi, China, 100142
Second Affiliated Hospital of Zhejiang University School of Medicine
88 Jie Fang Lu, Shang Cheng Qu, Hang Zhou Shi, Zhe Jiang Sheng, China, 310009
Shandong Cancer Hospital
Shizhong District, Jinan, Jinan, China, 250000
Weihai Municipal Hospital
Weihai, Shandong, China
The First Affiliated Hospital of Nanchang University
China, Jiang Xi Sheng, Nan Chang Shi, Nan Chang Xian, 桃花东路 邮政编码: 330209
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
Hubei Cancer Hospital
16 Zhuo Dao Quan Nan Lu, Hong Shan Qu, Wu Han Shi, Hu Bei Sheng, China, 430079
Cancer Hospital affiliated to Xinjiang Medical University
393 Xin Yi Lu, Xin Shi Qu, Wu Lu Mu Qi Shi, Xin Jiang Wei Wu Er Zi Zhi Qu, China, 830011
Attikon University General Hospital
Rimini 1, Chaidari 124 62, Greece
Agios Loucas Clinic SA
Panorama 552 36, Greece
Severance Hospital Yonsei University Health System - PPDS
Seodaemun-gu, Seoul, South Korea
Kangbuk Samsung Hospital
29 Saemunan-ro, Jongno-gu, Seoul, South Korea
Cardiomed SRL
Strada Republicii 17, Cluj-Napoca 400015, Romania
Prof Dr I Chiricuta Institute of Oncology - PPDS
Strada Sindicatelor 7, Cluj-Napoca 400000, Romania
Medisprof SRL
Bulevardul Muncii 96, Cluj-Napoca 400641, Romania
Onco Clinic Consult SA
Craiova, Romania
Oncology Center Sfantul Nectarie
Craiova, Romania
Hospital Universitario Vall d'Hebron - PPDS
Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain
Hospital Universitari de Girona Dr Josep Trueta
Avinguda de França, S/N, 17007 Girona, Spain
Hospital Universitario Marques de Valdecilla
Av. de Valdecilla, 25, 39008 Santander, Cantabria, Spain
Municipal Non-profit Enterprise "City Clinical Hospital # 4" of Dnipro City Council - PPDS
Blyzhnya St, 31, Dnipropetrovs'k, Dnipropetrovs'ka oblast, Ukraine, 49000
Communal Non-profit Enterprise Regional Center of Oncology
Kharkiv, Kharkiv Oblast, Ukraine
Medical Center of Limited Liability Company "Medical center "VERUM EXPERT"
Kyiv, Ukraine, 02000
Treatment and Diagnostic Center of LLC Specialized Clinic Prognosis Optima
Kyiv, Ukraine, 02000
SI "National Institute of Surgery and Transplantology n.a. O.O. Shalimov " of NAMS of Ukraine
Kyiv, Ukraine, 02000
Communal Nonprofit Enterprise Kyiv City Clinical Oncological Center
Fedora Maksymenka St, 26, Kyiv, Ukraine, 04075
Municipal Non-profit Enterprise "Odessa Regional Oncology Dispensary" of Odesa RC
Odesa, Odessa Oblast, Ukraine, 65000
Instituto de Investigaciones Metabólicas - IDIM
Libertad 836, C1012AAR CABA, Argentina
Fundación Centro de Medicina Nuclear y Molecular ER
Córdoba, Cordoba, Argentina
Centro Médico Privado CEMAIC
Av. Monseñor Pablo Cabrera 2941, X5008 HHW, Córdoba, Argentina
Research Site
Parque Patricios, Buenos Aires, Argentina
Centro de Investigación Pergamino S.A.
Av. de Mayo 1115, B2700CPM Pergamino, Provincia de Buenos Aires, Argentina
Centro de Investigaciones Médicas Tucumán
Centro, San Miguel de Tucumán, Tucumán, Argentina
Research Site
Viedma, Río Negro, Argentina
Border Medical Oncology Research Unit
201 Borella Rd, East Albury NSW 2640, Australia
Flinders Medical Centre
Flinders Dr, Bedford Park SA 5042, Australia
Austin Health
145 Studley Rd, Heidelberg VIC 3084, Australia
Liverpool Hospital
75 Elizabeth St, Liverpool NSW 2170, Australia
Fiona Stanley Hospital
11 Robin Warren Dr, Murdoch WA 6150, Australia
Imelda VZW
Imeldalaan 9, 2820 Bonheiden, Belgium
Cliniques Universitaires Saint-Luc
Av. Hippocrate 10, 1200 Bruxelles, Belgium
UZ Gent
UGent, 9000 Gent, Belgium
UZ Leuven
Herestraat 49, 3000 Leuven, Belgium
Research Site
Liège, Belgium
Research Site 1
Barretos - State of São Paulo, Brazil
Research Site 2
Barretos - State of São Paulo, Brazil
Research Site
Belo Horizonte, State of Minas Gerais, Brazil
Research Site
Brasília - Brasilia, Federal District, Brazil
Research Site
Fortaleza - State of Ceará, Brazil
Research Site
Ijuí, RS, 98700-000, Brazil
Hospital de Clinicas de Porto Alegre (HCPA) - PPDS
Rua Ramiro Barcelos, 2350 - Av. Protásio Alves, 211 - Santa Cecília, Porto Alegre - RS, 90035-903, Brazil
Irmandade Da Santa Casa de Misericordia de Porto Alegre
Av. Independência, 155 - Independência, Porto Alegre - RS, 90035-074, Brazil
Research Site 1
Porto Alegre, RS, Brazil
Research Site 2
Rua Vítor Hugo, 37 - Petrópolis, Porto Alegre - RS, 90630-070, Brazil
Research Site
Rio de Janeiro, State of Rio de Janeiro, Brazil
Research Site
Santo André, State of São Paulo, Brazil
Research Site
Sorocaba - State of São Paulo, Brazil
Research Site
São Paulo, State of São Paulo, Brazil
Research Site
Toronto, ON, Canada
Corporacion de Beneficencia Osorno
Osorno, 5290000, Los Lagos, Chile
Research Site
Providencia, Santiago Metropolitan Region, Chile
Meditek Ltda
Av. Recoleta, Santiago, Región Metropolitana, Chile
Icegclinic
Santiago, Santiago Metropolitan Region, Chile
Sociedad de Investigaciones Medicas Limitada
Temuco, Araucania, Chile
Beijing Chao-Yang Hospital, Capital Medical University
WFF2+WP8, Dong Da Qiao Xie Jie, 使馆区 Chao Yang Qu, Bei Jing Shi, China, 100020
Peking University Third Hospital
49 Hua Yuan Bei Lu, Hai Dian Qu, Bei Jing Shi, China, 100191
Beijing Hospital
Beijing, China
Beijing Luhe Hospital, Capital Medical University
82 Xin Hua Nan Lu, Tong Zhou Qu, Bei Jing Shi, China, 101199
Research Site 1
Beijing, China
Research Site 2
Beijing, China
The First Affiliated Hospital of Bengbu Medical College
2600 Dong Hai Da Dao, Long Zi Hu Qu, Beng Bu Shi, An Hui Sheng, China, 233030
Research Site
Changchun, Jilin, China
Hunan Cancer Hospital
China, Hu Nan Sheng, Chang Sha Shi, Yue Lu Qu, 582, 湖南省肿瘤医院 邮政编码: 410006
Changzhi People Hospital
502 Chang Xing Zhong Lu, Shang Dang Qu, Chang Zhi Shi, Shan Xi Sheng, China, 046099
The First People's Hospital of Changzhou
185 Ju Qian Jie, Tian Ning Qu, Chang Zhou Shi, Jiang Su Sheng, China, 213003
Sichuan Cancer Hospital & Institute
55 Ren Min Nan Lu Si Duan, Wu Hou Qu, Cheng Du Shi, Si Chuan Sheng, China, 610044
The First Affiliated Hospital of Fujian Medical University
20 Cha Zhong Lu, Tai Jiang Qu, Fu Zhou Shi, Fu Jian Sheng, China, 350004
Fujian Cancer Hospital
Fuzhou, China, 350014
Guangdong Provincial People's Hospital
1 Shi Liu Gang Lu, Hai Zhu Qu, Guang Zhou Shi, Guang Dong Sheng, China, 510317
The Sixth Affiliated Hospital of Sun Yat-sen University
4997+2G3, Yuan Cun Er Heng Lu, Tian He Qu, Guang Zhou Shi, Guang Dong Sheng, China, 510655
Hainan General Hospital
14 Mei Su Lu, Xiu Ying Qu, Hai Kou Shi, Hai Nan Sheng, China, 570311
The First Affiliated Hospital, College of Medicine, Zhejiang University
866 Yu Hang Tang Lu, Xi Hu Qu, Hang Zhou Shi, Zhe Jiang Sheng, China, 310027
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
China, Zhe Jiang Sheng, Hang Zhou Shi, Jiang Gan Qu, 城东庆春东路3号 邮政编码: 310016
Zhejiang Cancer Hospital
953R+42X, Shan Qian Zhi Lu, Gong Shu Qu, Hang Zhou Shi, Zhe Jiang Sheng, China, 310022
Harbin Medical University Cancer Hospital
157 Bao Jian Lu, Nan Gang Qu, Ha Er Bin Shi, Hei Long Jiang Sheng, China, 150088
Anhui Provincial Cancer Hospital
Shushan District, Hefei, China, 230031
The Second Affiliated Hospital of Anhui Medical University
Hefei, China, 230601
Research Site
Hohhot, Inner Mongolia, China
Jinan Cancer Hospital
Lixia District, Jinan, China, 250013
Research Site
Jining, Shandong, China
Yunnan Cancer Hospital
Xishan, Kunming, China, 650118
The First Hospital of Lanzhou University
2VWC+25M, Rui De Da Dao, Cheng Guan Qu, Lan Zhou Shi, Gan Su Sheng, China, 730013
Gansu Provincial Cancer Hospital
2 Xiao Xi Hu Dong Jie, Qi Li He Qu, Lan Zhou Shi, Gan Su Sheng, China, 730031
Nanjing Drum Tower Hospital ,The Affiliated Hospital of Nanjing University Medical School
321 Zhong Shan Lu, Gu Lou Qu, Nan Jing Shi, Jiang Su Sheng, China, 210008
The Affiliated Hospital of Qingdao University
China, Shan Dong Sheng, Qing Dao Shi, Shi Nan Qu, 江苏路16号 邮政编码: 266005
Ruijin hospital Shanghai Jiao Tong University School of Medicine
227 Chong Qing Nan Lu, Lu Wan Qu, Shang Hai Shi, China, 200025
Fudan University Affiliated Zhongshan Hospital
180 Feng Lin Lu, Xu Hui Qu, Shang Hai Shi, China, 200031
Shanghai 10th People's Hospital
China, 200072
Shanghai East Hospital
Shang Hai Shi Dong Fang Yi Yuan, 甲秀里 Pu Dong Xin Qu, Shang Hai Shi, China, 200120
Research Site 1
Shanghai, China
Research Site 2
Shanghai, China
Shangrao People's Hospital
86 Shu Yuan Lu, Xin Zhou Qu, Shang Rao Shi, Jiang Xi Sheng, China, 334000
Liaoning Cancer Hospital & Institute
Shenyang, Liaoning, China
Research Site 1
Shenyang, Liaoning, China
Peking University Shenzhen Hospital
1120 Lian Hua Lu, Fu Tian Qu, Shen Zhen Shi, Guang Dong Sheng, China, 518036
Research Site
Shenzhen, Guangdong Province, China
The Fourth Hospital of Hebei Medical University
3G25+5VR, Jian Kang Lu, Qiao Dong Qu, Shi Jia Zhuang Shi, He Bei Sheng, China, 050010
Tianjin Medical University Cancer Institute & Hospital
35JM+2JF, Bin Shui Dao, He Xi Qu, Tian Jin Shi, China, 300060
Weihai Municipal Hospital
China, Shan Dong Sheng, Wei Hai Shi, Huan Cui Qu, 和平路70号 邮政编码: 264299
Affiliated Hospital of Jiangnan University
1800 Li Hu Da Dao, Bin Hu Qu, Wu Xi Shi, Jiang Su Sheng, China, 214126
First Affiliated Hospital of Xi 'an Jiaotong University
Xi An Jiao Tong Da Xue Yi Xue Yuan Di Yi Fu Shu Yi Yuan, 和平门 Yan Ta Qu, Xi An Shi, Shan Xi Sheng, China, 710063
Research Site
Xi'An, Shaanxi, China
Research Site
Xiamen, Fujian, China
Northern Jiangsu People's Hospital
98 Nan Tong Xi Lu, 98, Guang Ling Qu, Yang Zhou Shi, Jiang Su Sheng, China, 225001
Research Site
Yangzhou, Jiangsu, China
Henan Cancer Hospital
China, He Nan Sheng, Zheng Zhou Shi, Jin Shui Qu, 东明路127号 邮政编码: 450003
The First Affiliated Hospital of Zhengzhou University
China, He Nan Sheng, Zheng Zhou Shi, Er Qi Qu, 建设东路1号 邮政编码: 450052
Research Site
Zhengzhou, Henan, China
Cancer Hospital affiliated to Xinjiang Medical University
393 Xin Yi Lu, Xin Shi Qu, Wu Lu Mu Qi Shi, Xin Jiang Wei Wu Er Zi Zhi Qu, China, 830011
Fakultni nemocnice Olomouc
Sokolská 581, 500 03 Hradec Králové, Czechia
East Tallinn Central Hospital
Ravi 18, 10138 Tallinn, Estonia
North Estonia Medical Centre Foundation
J. Sütiste tee 19, 13419 Tallinn, Estonia
Institut Sainte Catherine
250 Chem. de Baigne Pieds, 84918 Avignon, France
Hopital Jean Minjoz
3 Bd Alexandre Fleming, 25000 Besançon, France
EDOG - Institut Bergonie - PPDS
229 Cr de l'Argonne, 33076 Bordeaux, France
Universite de Bourgogne - Faculte de Medecine - IN
Maison de l'Université, Esp. Erasme, 21078 Dijon, France
Centre Hospitalier Universitaire Grenoble Alpes - Hopital Albert Michallon
Av. des Maquis du Grésivaudan, 38700 La Tronche, France
Research Site
Lyon, France
Research Site
Nantes, France
CHRU de Poitiers La Miletrie
2 Rue de la Milétrie, 86000 Poitiers, France
EDOG - Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer - PPDS
Av. de la Bataille Flandres-Dunkerque CS 44229, 35000 Rennes, France
CHRU de Brest - Hopital Morvan
42270 St-Priest-en-Jarez, France
Hôpital de Rangueil
1 Av. du Professeur Jean Poulhès, 31400 Toulouse, France
Hôpital Saint Antoine
184 Rue du Faubourg Saint-Antoine, 75012 Paris, France
Research Site 1
Tbilisi, Georgia
Research Site 2
Tbilisi, Georgia
Research Site 3
Tbilisi, Georgia
Research Site 4
Tbilisi, Georgia
Research Site
Frankfurt, Germany
Research Site
Hanover, Germany
Research Site
Leipzig, Germany
Research Site
Trier, Germany
Research Site
Ulm, Germany
Aretaieio Hospital of Athens
Vasilissis Sofias 76, Athina 115 28, Greece
Attikon University General Hospital
Rimini 1, Chaidari 124 62, Greece
Research Site
Pireas, Greece
Celan S.A.
Grupo AMI, 5 Avenida 31-3, Cdad. de Guatemala, Guatemala
Integra Cancer Institute
Guatemala City, Guatemala
Grupo Medico Angeles
2da calle 25-19 zona 15 Vista Hermosa I, Edif, Edificio Multimédica, 10-15, Cdad. de Guatemala 01015, Guatemala
Centro Medico Integral de Cancerologia CEMIC
Salcajá, Guatemala
Research Site
Hong Kong
Research Site
Kowloon, Hong Kong
Research Site
Bengaluru, Karnataka, India
Research Site
6MXH+6QM, Khurdha - Chandaka Rd, Chatabar, Odisha 752054, India
Research Site
Gurugram, Haryana, India
Research Site
Hyderabad, Telangana, India
Research Site
Jaipur, Rajasthan, India
Curie Manavata Cancer Centre
HCG Manavata Cancer Centre, near Mylan Circle, Mumbai Naka, Renuka Nagar, Nashik, Maharashtra 422002, India
Research Site
New Delhi, Delhi, India
Research Site
Patna, Bihar, India
Research Site
Pune, Maharashtra, India
HCG City Cancer Center
#44-1-1/3, Padavalarevu, Gunadala, Vijayawada, Andhra Pradesh 520004, India
Research Site
Dublin, Ireland
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi
Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy
Fondazione del Piemonte per l'Oncologia (IRCCS)
SP142 km 3,95, 10060 Candiolo TO, Italy
Research Site
Genoa, Metropolitan City of Genoa, Italy
Research Site
47014 Meldola, Province of Forlì-Cesena, Italy
ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda
Piazza dell'Ospedale Maggiore, 3, 20162 Milano MI, Italy
Research Site 1
Zone 1 of Milan, Milan, Metropolitan City of Milan, Italy
Research Site 2
Milan, Metropolitan City of Milan, Italy
Research Site
Modena, Province of Modena, Italy
Research Site
Reggio Emilia, Province of Reggio Emilia, Italy
Fondazione Policlinico Universitario A Gemelli
Via Giuseppe Moscati, 31, 00168 Roma RM, Italy
Research Site
Turin, Metropolitan City of Turin, Italy
Centro Ricerche Cliniche Di Verona
Piazzale L.A. Scuro, 10, 37134 Verona VR, Italy
Azienda ULSS 8 "Berica" - Ospedale San Bortolo
Viale Ferdinando Rodolfi, 37, 36100 Vicenza VI, Italy
National Cancer Center
Goyang-si, Gyeonggi-do, South Korea
CHA Bundang Medical Center, CHA University
Bundang Cha Medical Center, Bundang Public Health Center, Seongnam-si, South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital
222 Banpo-daero, Seocho-gu, Seoul, South Korea
Severance Hospital Yonsei University Health System - PPDS
50-1 Yonsei-ro, Sinchon-dong, Seodaemun-gu, Seoul, South Korea
Gangnam Severance Hospital, Yonsei University Health System
211 Eonju-ro, Gangnam-gu, Seoul, South Korea
Research Site
George Town, Penang, Malaysia
Research Site 1
Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia
Research Site 2
2, Federal Territory of Kuala Lumpur, Malaysia
Research Site
Kuching, Sarawak, Malaysia
Research Site
Putrajaya, Malaysia
Cryptex Investigación Clínica, S.A. de C.V.
Calle de Durango 216, Roma Nte., Cuauhtémoc, 06700 Ciudad de México, CDMX, Mexico
Research Site 1
Mexico City, CDMX, Mexico
Research Site 2
Mexico City, CDMX, Mexico
Hospital Universitario Dr. Jose Eleuterio González
Av. Dr. José Eleuterio González S/N, Mitras Centro, 64460 Monterrey, N.L., Mexico
Centro de Investigacion Clinica de Oaxaca
A San Luis Beltrán 120, Jardin, 68020 Oaxaca de Juárez, Oax., Mexico
Research Site
Eindhoven, Netherlands
Universitair Medisch Centrum Groningen
Hanzeplein 1, 9713 GZ Groningen, Netherlands
Research Site
Leiden, Netherlands
ETZ-Elisabeth
Hilvarenbeekse Weg 60, 5022 GC Tilburg, Netherlands
Research Site
Arequipa, Peru
Research site
Bellavista, Peru
Research Site
Chiclayo, Peru
Research Site
Jesús María, Peru
Research Site 1
Lima, Peru
Research Site 2
Lima, Peru
Research Site 3
Lima, Peru
Research Site 4
Lima, Peru
Research Site
Santiago de Surco, Peru
Research Site 1
Trujillo, Peru
Research Site 2
Trujillo, Peru
Centrum Medyczne Poznan - PRATIA - PPDS
Przemysłowa 46A, 61-541 Poznań, Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi
Pabianicka 62, 93-513 Łódź, Poland
Hospital Garcia de Orta
Av. Torrado da Silva, 2805-267 Almada, Portugal
Centro Hospitalar E Universitário de Coimbra EPE
Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal
Hospital Senhora da Oliveira - Guimaraes, E.P.E
R. dos Cutileiros 114, 4805 Creixomil, Portugal
Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria
Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal
Hospital Beatriz Angelo
Hospital Beatriz Ângelo, 2670 Loures, Portugal
Unidade Local de Saúde de Matosinhos SA
Matosinhos, Portugal
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS
4200 Porto, Portugal
Research Site 1
Porto, Portugal
Research Site 2
Porto, Portugal
Fundeni Clinical Institute
Calea București 258, București, Romania
Institutul Regional de Oncologie Iasi
Strada General Henri Mathias Berthelot 2-4, Iași 700483, Romania
Research Site 1
Belgrade, Serbia
Research Site 2
Belgrade, Serbia
Research Site 3
Belgrade, Serbia
Research Site 4
Belgrade, Serbia
Research site
Niš, Serbia
Research Site
Sremska Kamenica, Serbia
Research site 1
Singapore
Research site 2
Singapore
Cape Town Oncology Trials
51 Tiger Ave, Windsor Park, Cape Town, 7570, South Africa
Research site
Mogale City, South Africa
University of Pretoria
Lynnwood Rd, Hatfield, Pretoria, 0002, South Africa
Wilgers Oncology Centre
Wilgers Hospital, Denneboom Rd, Die Wilgers, Pretoria, 0001, South Africa
Hospital Universitario Germans Trias i Pujol
Carretera de Canyet, s/n, 08916 Badalona, Barcelona, Spain
ICO l'Hospitalet - Hospital Duran i Reynals
Avinguda de la Granvia de l’Hospitalet, 199, 08908 L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario Ramon y Cajal
M-607, 9, 100, 28034 Madrid, Spain
Hospital Universitario 12 de Octubre
Av. de Córdoba, s/n, 28041 Madrid, Spain
Hospital Regional Universitario de Malaga - Hospital General
Av. de Carlos Haya, 84, 29010 Málaga, Spain
Complejo Asistencial Universitario de Salamanca - H. Clinico
P.º de San Vicente, 58, 37007 Salamanca, Spain
Hospital Universitario Virgen Macarena
Av. Dr. Fedriani, 3, 41009 Sevilla, Spain
Hospital Clinico Universitario de Valencia
Av. de Blasco Ibáñez, 17, 46010 València, Valencia, Spain
China Medical University Hospital
No. 2, Yude Rd, North District, Taichung City, Taiwan 404
Chi Mei Medical Center
No. 901號, Zhonghua Rd, Yongkang District, Tainan City, Taiwan 710
Mackay Memorial Hospital
No. 92號, Section 2, Zhongshan N Rd, Zhongshan District, Taipei City, Taiwan 104
Taipei Veterans General Hospital
No. 201, Section 2, Shipai Rd, Beitou District, Taipei City, Taiwan 112
Research site
Bangkok Noi, Bangkok 10700, Thailand
Bangkok Metropolitan Administration Medical College and Vajira Hospital
681 Thanon Samsen, Khwaeng Wachira Phayaban, Khet Dusit, Krung Thep Maha Nakhon 10300, Thailand
Phramongkutklao Hospital
315 Thanon Ratchawithi, Khwaeng Thung Phaya Thai, Khet Ratchathewi, Krung Thep Maha Nakhon 10400, Thailand
Prince of Songkla University
15 ถนน กาญจนวณิชย์ Tambon Kho Hong, Amphoe Hat Yai, Chang Wat Songkhla 90110, Thailand
Research Site
Khon Kaen, Mueang Khon Kaen District, Khon Kaen 40000, Thailand
Chulaborn Hospital
100 ซอย วิภาวดีรังสิต Khwaeng Thung Song Hong, Khet Lak Si, Krung Thep Maha Nakhon 10210, Thailand
Research site 1
Phitsanulok, Nai Mueang, Mueang Phitsanulok District, Phitsanulok 65000, Thailand
Research site 2
Phitsanulok, Nai Mueang, Mueang Phitsanulok District, Phitsanulok 65000, Thailand
Research site
Antalya, Turkey
Research site
Balçova/İzmir, Turkey
Research site
Bursa, Turkey
Research site
Denizli, Kumkısık, Denizli, Turkey
Research site
Edirne, Edirne Merkez/Edirne, Turkey
Research site
Fatih, Topkapı, 34093 Fatih/İstanbul, Turkey
Research site
Sur/Diyarbakır, Turkey
Research site
Tarabya, 34457 Sarıyer/İstanbul, Turkey
Research site
Trabzon, Ortahisar/Trabzon, Turkey
Research site
Yenimahalle/Ankara, Turkey
Research site
Ankara, Turkey
Bristol Haematology and Oncology Centre
22 Horfield Rd, Bristol BS2 8ED, UK
Research site
Edgbaston, Birmingham B15 2UR, UK
Western General Hospital Edinburgh - PPDS
Crewe Rd S, Edinburgh EH4 2XU, UK
St James University Hospital
Beckett St, Harehills, Leeds LS9 7TF, UK
Research site 1
London, UK
Research site 2
London, UK
Research site 3
Site 3, The Broadway, Greenford UB6 9PH, UK
Research site
Northwood, UK
Edith Cavell Hospital
Edith Cavell Campus, Bretton Gate, Peterborough PE3 9GZ, UK
Research site
Sheffield, UK
National Cancer Centre Singapore
Curie Oncology (Farrer)
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
Centro de Investigación Clínica - Clínica Viedma
Viedma, Río Negro, Argentina
CHU de Liège
Avenue de l'Hôpital 1, 4000 Luik, Belgium
Fundação Pio XII Hospital de Câncer de Barretos
R. Antenor Duarte Viléla, 1331 - Dr. Paulo Prata, Barretos - SP, 14784-400, Brazil
Hospital de Base Da Faculdade de Medicina de São José Do Rio Preto
Av. Brg. Faria Lima, 5544 - Vila Sao Jose, São José do Rio Preto - SP, 15090-000, Brazil
Hospital Amaral Carvalho
Brasília - Brasilia, Federal District, Brazil
Instituto Do Câncer Do Ceará ICC
R. Papi Júnior, 1220 - Rodolfo Teófilo, Fortaleza - CE, 60430-230, Brazil
Associação Hospital de Caridade Ijuí
Av. David José Martins, 152 - Centro, Ijuí - RS, 98700-000, Brazil
Hospital Sao Lucas da PUCRS
Av. Ipiranga, 6690 - Partenon, Porto Alegre - RS, 90610-001, Brazil
Hospital Nossa Senhora Da Conceição
Av. Francisco Trein, 596 - Cristo Redentor, Porto Alegre - RS, 91350-200, Brazil
INCA - Instituto Nacional de Câncer José Alencar G
Santa Teresa, Rio de Janeiro - State of Rio de Janeiro, 20231-050, Brazil
Instituto Brasileiro de Controle Do Câncer IBCC
Instituto Brasileiro De Controle Do Câncer - Mooca, São Paulo - SP, 03163-060, Brazil
Instituto de Oncologia de Sorocaba
Av. Comendador Pereira Inácio, 950 - Jardim Vergueiro, Sorocaba - SP, 18030-005, Brazil
Instituto do Cancer do Estado de São Paulo ICESP
Av. Dr. Arnaldo, 251 - Cerqueira César, São Paulo - SP, 01246-000, Brazil
Princess Margaret Cancer Centre
610 University Ave, Toronto, ON M5G 2C4, Canada
Cancer Hospital Chinese Academy of Medical Sciences
China, Bei Jing Shi, Chao Yang Qu, Nan Si Huan Dong Lu Fu Lu, 吕家营南里237号 邮政编码: 100023
Peking Union Medical College Hospital
Bei Jing Xie He Yi Yuan, Fangzhuang, Dong Cheng Qu, Bei Jing Shi, China, 100006
Affiliated Hospital of Inner Mongolia Medical University
PCVQ+96H, Jin Shan Da Dao, Tu Mo Te Zuo Qi, Hu He Hao Te Shi, Nei Meng Gu Zi Zhi Qu, China, 010107
The First Hospital of China Medical University
Heping District, Shenyang, Shenyang, China, 110001
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, China
Centre Léon Berard
28 Prom. Léa et Napoléon Bullukian, 69008 Lyon, France
EDOG Institut de Cancerologie de l'Ouest - PPDS
Bd Professeur Jacques Monod, 44800 Saint-Herblain, France
The Bangalore Hospital
202, Rashtriya Vidyalaya Rd, Jaya Nagar 1st Block, Basavanagudi, Bengaluru, Karnataka 560004, India
All India Institute of Medical Sciences, Bhubaneswar
Sijua, Patrapada, Bhubaneswar, Odisha 751019, India
Artemis Hospital
Sector 51, Gurugram, Haryana 122001, India
MNJ Institute of Oncology and Regional Cancer Centre
Taj Enclave, Nampally, Hyderabad, Telangana 500004, India
Indraprastha Apollo Hospitals
Indraprastha Apollo Hospital, Mathura Rd, Jasola, New Delhi, Delhi 110076, India
Regional Cancer Centre Indira Gandhi Institute of Medical Sciences
Allahabad bank, Bailey Rd, Sheikhpura, Patna, Bihar 800014, India
Deenanath Mangeshkar Hospital and Research Centre
DEENANATH MANGESHKAR HOSPITAL AND RESEARCH CENTER, Deenanath Mangeshkar Hospital Road, वकिल नगर, एरंडवणे, पुणे, महाराष्ट्र 411004, India
St James's Hospital
James St, Saint James' (part of Phoenix Park), Dublin 8, D08 NHY1, Ireland
Ospedale Policlinico San Martino
Largo Rosanna Benzi, 10, 16132 Genova GE, Italy
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS
Meldola (IRST), 47014 Meldola FC, Italy
Ospedale San Raffaele S.r.l. - PPDS
Via Ponte Nuovo, 31, 20128 Milano MI, Italy
Research Site
Milan, Metropolitan City of Milan, Italy
Azienda Ospedaliero Universitaria Di Modena Policlinico
Largo del Pozzo, 71, 41125 Modena MO, Italy
Hospital Pulau Pinang
Jln. Utama, 10450 George Town, Pulau Pinang, Malaysia
Pantai Hospital Kuala Lumpur
8, Jalan Bukit Pantai, Bangsar, 59100 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
University Malaya Medical Centre
Jln Profesor Diraja Ungku Aziz, Lembah Pantai, 59100 Kuala Lumpur, Selangor, Malaysia
Sarawak General Hospital
Jalan Hospital, 93586 Kuching, Sarawak, Malaysia
National Cancer Institute ( Institut Kanser Negara)
Putrajaya, Malaysia
Catharina Hospital
Michelangelolaan 2, 5623 EJ Eindhoven, Netherlands
Leids Universitair Medisch Centrum
Albinusdreef 2, 2333 ZA Leiden, Netherlands
Centro Hospitalar do Porto EPE
Largo do Prof. Abel Salazar, 4099-001 Porto, Portugal
Military Medical Academy
Crnotravska 17, Beograd 11000, Serbia
University Clinical Center of Serbia - PPDS
Pasterova 2, Beograd 11000, Serbia
Clinical Hospital Center Bezanijska Kosa
Bežanijska kosa, Beograd, Serbia
Research Site
Belgrade, Serbia
University Clinical Center Nis
Bulevar Dr Zorana Đinđića 48, Niš 18000, Serbia
Oncology Institute of Vojvodina
Sremska Kamenica, Serbia
Oncocare Cancer Centre
6 Napier Rd, #02-17/18/19 Gleneagles Medical Centre, Singapore 258499
Icon Cancer Centre Farrer Park
1 Farrer Park Station Rd, Singapore 217562
Curie Oncology
38 Irrawaddy Rd, #08 21/29/30, Singapore 329563
Siriraj Hospital Mahidol University
2 Thanon Wang Lang, Khwaeng Siriraj, Khet Bangkok Noi, Krung Thep Maha Nakhon 10700, Thailand
Srinagarind Hospital, Khon Kaen University
123 หมู่ที่ 16 Tambon Nai Mueang, Amphoe Mueang Khon Kaen, Chang Wat Khon Kaen 40002, Thailand
Naresuan University
99 หมู่ที่ 9 ถนน พิษณุโลก-นครสวรรค์ Tambon Tha Pho, Amphoe Mueang Phitsanulok, Chang Wat Phitsanulok 65000, Thailand
Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital
St Thomas' Hospital, Westminster Bridge Rd, London SE1 7EH, UK
Royal Marsden Hospital - London
203 Fulham Rd., London SW3 6JJ, UK
Royal Marsden Hospital - Surrey
203 Fulham Rd., London SW3 6JJ, UK
Mount Vernon Hospital
Rickmansworth Rd, Northwood HA6 2RN, UK
Weston Park Cancer Centre
Whitham Rd, Broomhall, Sheffield S10 2SJ, UK
Cenantron - Centro Avancado de Tratamento Oncologico Ltda
R. Padre Rolim, 120 - Santa Efigênia, Belo Horizonte - MG, 30130-090, Brazil
Istituto Nazionale Dei Tumori
Via Giacomo Venezian, 1, 20133 Milano MI, Italy
Arcispedale Santa Maria Nuova
Viale Risorgimento, 80, 42123 Reggio Emilia RE, Italy
Southern Cross Research South Africa (PTY) LTD
Mogale City, South Africa
Hospital de Gastroenterología Dr Bonorino Udaondo
Av. Caseros 2061, C1264AAA Buenos Aires, Argentina
Fudan University Shanghai Cancer Center
270 Dong An Lu, 270, Xu Hui Qu, Shang Hai Shi, China, 200032
Shanghai General Hospital
China, Shang Hai Shi, Song Jiang Qu, 新松江路650号 邮政编码: 201613
Shenzehen People's Hospital
Shen Zhen Shi Ren Min Yi Yuan, 园岭 Luo Hu Qu, Shen Zhen Shi, Guang Dong Sheng, China, 518001
LTD TIM, Tbilisi Institute of Medicine
Tbilisi, Georgia
Research Institute of Clinical Medicine
Tbilisi, Georgia
Tbilisi State Medical University's and Ingorokva's University Clinic of High Medical Technologies
Tbilisi, Georgia
High Technology Hospital MedCenter Ltd
Tbilisi, Georgia
Medizinische Hochschule Hannover
Carl-Neuberg-Straße 1, 30625 Hannover, Germany
Universitaetsklinikum Leipzig
Liebigstraße 20, 04103 Leipzig, Germany
Universitaetsklinikum Ulm
Albert-Einstein-Allee 23, 89081 Ulm, Germany
Azienda Ospedaliera Città della Salute e della Scienza di Torino
Via Genova, 23, 10126 Torino TO, Italy
Kyoto University Hospital
54 Shogoin Kawaracho, Sakyo Ward, Kyoto, 606-8397, Japan
Osaka University Hospital
2-15 Yamadaoka, Suita, Osaka 565-0871, Japan
National Cancer Center Hospital East
Japan, 〒277-8577 Chiba, Kashiwa, Kashiwanoha, 6-chōme−５−１
National Cancer Center Hospital
5-chōme-1-1 Tsukiji, Chuo City, Tokyo 104-0045, Japan
Shikoku Cancer Center
甲１６０ Minamiumemotomachi, Matsuyama, Ehime 791-0245, Japan
Aichi Cancer Center
1-1 Kanokoden, Chikusa Ward, Nagoya, Aichi 464-8681, Japan
Kindai University Hospital
377-2 Ōnohigashi, Osakasayama, Osaka 589-8511, Japan
Osaka International Cancer Institute
3-chōme-1-69 Ōtemae, Chuo Ward, Osaka, 540-0008, Japan
Shizuoka Cancer Center
1007 Shimonagakubo, Nagaizumi, Sunto District, Shizuoka 411-8777, Japan
The Cancer Institute Hospital of Japanese Foundation For Cancer Research
3-chōme-8-31 Ariake, Koto City, Tokyo 135-0063, Japan
Clinstile, S.A. de C.V.
Del. Cuauhtémoc, Calle de Durango 325-int 603, Roma Nte., Cuauhtémoc, 06700 Ciudad de México, CDMX, Mexico
Institute for Oncology and Radiology of Serbia - PPDS
Pasterova 14, Beograd, Serbia
National Cancer Center Singapore
Singapore 119074
Hacettepe Universitesi Kanser Enstitusu
Hacettepe, Hacettepe University Oncology Hospital, 06590 Altındağ/Ankara, Türkiye
Antalya Yaşam Onkoloji Merkezi
Gebizli, 1116. Sk. No:4, 07300 Muratpaşa/Antalya, Türkiye
Acibadem Maslak Hospital
Darüşşafaka, Büyükdere Cd. No:40, 34398 Sarıyer/İstanbul, Türkiye
Acibadem Adana Hospital
Döşeme, Cumhuriyet Cd. No:66, 01130 Seyhan/Adana, Türkiye
Gifu University Hospital
１番１ Yanagido, Gifu, 501-1112, Japan
Fukui Prefectural Hospital
2-chōme-8-1 Yotsui, Fukui, 910-0846, Japan
Hyogo Cancer Center
13-70 Kitaōjichō, 北王子町 Akashi, Hyogo 673-0021, Japan
Kobe City Medical Center General Hospital
Japan, 〒650-0047 Hyogo, Kobe, Chuo Ward, Minatojima Minamimachi, 2-chōme−１−１
Ibaraki Prefectural Central Hospital
6528 Koibuchi, Kasama, Ibaraki 309-1703, Japan
Kanagawa Cancer Center
2-chōme-3-2 Nakao, Asahi Ward, Yokohama, Kanagawa 241-8515, Japan
Osaki Citizen Hospital
3-chōme-8-1 Furukawahonami, Ōsaki, Miyagi 989-6136, Japan
Kurashiki Central Hospital
1-chōme-1-1 Miwa, Kurashiki, Okayama 710-0052, Japan
Chiba Cancer Center
666-2 Nitonachō, Chuo Ward, Chiba, 260-0801, Japan
National Hospital Organization Kyushu Cancer Center
3-chōme-1-1 Notame, Minami Ward, Fukuoka, 811-1347, Japan
Istanbul Universitesi Cerrahpasa Tip Fakultesi
Cerrahpaşa, İstanbul Üniversiesi Cerrahpaşa Tıp Fakültesi, Koca Mustafapaşa Cd. No:53, 34098 Fatih/İstanbul, Türkiye
Akdeniz University Medical Faculty
Meltem, Dumlupınar Blv. Yanyolu No:171, 07030 Muratpaşa/Antalya, Turkey
Uludag Universites Tip Fakultesi Hastanesi
Özlüce Görükle Kampüsü, Özlüce, 16059 Nilüfer/Bursa, Türkiye
Dicle University Medical Faculty
Dicle Üniversitesi Rektörlüğü, 21280 Sur/Diyarbakır, Türkiye
Trakya University Medical Faculty
Trakya Ünv. Balkan Yerleşkesi, 22130 İskender/Edirne Merkez/Edirne, Turkey
Dokuz Eylul Universitesi
Kültür, Cumhuriyet Blv No:35210 no 144, 35220 Konak/İzmir, Türkiye
Medical Park Trabzon Yildizli
Merkez Mahallesi, Sahil Yolu Cd. No:46, 61310 Yıldızlı/Akçaabat/Trabzon, Türkiye